The bill establishes a new section in Wyoming law that explicitly prohibits health mandates and requirements related to COVID-19 and its variants as set forth by the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO). It asserts that these organizations will have no jurisdiction in Wyoming, meaning that any guidance, recommendations, or mandates issued by them regarding masks, vaccines, or medical testing for COVID-19 will not be enforceable within the state.

The legislation aims to ensure that Wyoming residents are not subject to federal or nongovernmental health organization mandates concerning COVID-19. It is set to take effect immediately upon the completion of all necessary legislative procedures as outlined in the Wyoming Constitution.