The bill establishes a new section in Wyoming law, specifically W.S. 35-4-1101, which prohibits the jurisdiction of the United States Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) within the state. It explicitly states that any requirements, mandates, recommendations, instructions, or guidance from these organizations regarding COVID-19 and its variants will not be binding in Wyoming. This means that the state will not enforce any mask, vaccine, or medical testing requirements related to COVID-19 as dictated by these federal and nongovernmental health organizations.

The act is designed to ensure that Wyoming maintains autonomy over public health decisions, particularly in relation to COVID-19. It is set to take effect immediately upon the completion of all necessary legislative processes as outlined in the Wyoming Constitution.