The bill establishes a new section in Wyoming law that explicitly prohibits health mandates and requirements related to COVID-19 and its variants as set forth by the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO). It asserts that these organizations will have no jurisdiction in Wyoming, and any guidance or recommendations they provide will not be binding within the state. This means that no mandates regarding masks, vaccines, or medical testing for COVID-19 can be enforced based on directives from these federal and nongovernmental health organizations.

The act is designed to ensure that Wyoming residents are not subject to health mandates imposed by external organizations, thereby reinforcing state autonomy in public health matters. The bill is set to take effect immediately upon the completion of all necessary legislative processes as outlined in the Wyoming Constitution.