The resolution declares the sovereign right of West Virginia to nullify any unconstitutional acts by the federal government, emphasizing the state's authority to protect its citizens' rights as outlined in both the West Virginia Constitution and the U.S. Constitution. It references various constitutional provisions and historical documents, including the writings of Thomas Jefferson and James Madison, to assert that the federal government has only limited, enumerated powers and that any actions beyond those powers are void. The resolution argues that the states have the right to interpose themselves against federal overreach and that the courts have historically usurped powers not granted to them by the Constitution.

Furthermore, the resolution mandates the Executive Branch of West Virginia to identify and take action against unconstitutional federal acts, and it encourages collaboration with other states to prevent the enforcement of such actions. It calls for the distribution of the resolution to key federal and state officials, inviting other states to join West Virginia in this effort to uphold constitutional governance and protect the rights of the people against federal encroachments.