H.R. No. 500 is a resolution recognizing March 21, 2025, as World Down Syndrome Day at the State Capitol of Texas. The resolution highlights the significance of Down syndrome, a chromosomal condition affecting approximately one in every 700 babies born in the U.S. It notes the advancements in medical care that have improved the life expectancy of individuals with Down syndrome, allowing them to lead fulfilling lives when provided with proper education, healthcare, and support from their communities. The resolution acknowledges the efforts of parents, medical professionals, and advocates in promoting inclusivity and securing the rights of individuals with Down syndrome.

The resolution also emphasizes the global recognition of World Down Syndrome Day, which was established by the United Nations General Assembly in 2011. It encourages all Texans to participate in fostering a culture of respect and inclusion for those living with Down syndrome. The resolution was adopted by the Texas House of Representatives on March 19, 2025, by a non-record vote, reflecting a collective commitment to raising awareness and supporting individuals with Down syndrome.