S.J.R. No. 3 proposes a constitutional amendment to establish the Dementia Prevention and Research Institute of Texas, along with the creation of the Dementia Prevention and Research Fund. This initiative aims to allocate $3 billion from the state general revenue to support research, prevention, and treatment of dementia, Alzheimer's disease, Parkinson's disease, and related disorders. The Institute will be responsible for awarding grants to educational institutions, medical research facilities, and other entities to facilitate research and develop therapies, as well as to implement prevention programs.

The resolution outlines the governance structure of the Institute, including six-year terms for its decision-making body, and specifies the funding sources for the Dementia Prevention and Research Fund, which will include the initial $3 billion transfer, legislative appropriations, and private donations. The proposed amendment will be presented to voters in an election scheduled for November 4, 2025, allowing them to decide on the establishment of the Institute and the associated funding for dementia-related research and treatment initiatives in Texas.