The bill establishes new provisions regarding the disclosure of COVID-19 vaccination status in relation to blood donations in South Dakota. It mandates that any individual or organization collecting human blood donations must require donors to disclose their COVID-19 vaccination status. If a donor has received the vaccine, the blood bag must be labeled to indicate this status, although the donor's personally identifiable information cannot be disclosed on the label.

Additionally, the bill allows individuals in nonemergent situations to request blood based on the vaccination status of the donor. Health care professionals are required to use the requested blood for transfusions if it is available at the facility where the individual is receiving care. This legislation aims to provide transparency and choice regarding blood transfusions in the context of COVID-19 vaccination.