This bill establishes new requirements for hospitals in Oklahoma regarding the identification and treatment of sepsis. It defines "sepsis" as a proven or suspected infection accompanied by a systemic inflammatory response and mandates that hospitals create, implement, and periodically update evidence-based protocols for early detection and treatment of sepsis and septic shock. The protocols must include screening for both healthcare-acquired and community-acquired sepsis, guidelines for treatment, and training for clinical staff. Additionally, the protocols must be tailored to specific populations, such as perinatal, neonatal, pediatric, and adult patients, ensuring that training materials reflect these variations.

Furthermore, the bill outlines clinical criteria for Medicaid and Medicare services related to sepsis, requiring third-party payors and managed care organizations to adhere to specific diagnostic standards. These standards include a provider's diagnosis of sepsis with a suspected or confirmed source of infection and the presence of two or more symptoms indicating an inflammatory response. The act is set to take effect on November 1, 2025.