Enacts GS 143B-437.84, establishing the NC Technology Coalitions Strategic Support Fund (Fund) within the Department of Commerce (Department). Directs that grants be awarded from the Fund by the Office of Science, Technology, and Innovation (Division). Grants the Board of Science, Technology, and Innovation (Board) oversight authority. Provides that the purpose of grants awarded from the Fund is to encourage regional technology-based economic growth by fostering collaboration throughout a technology coalition and aligning State resource investment to scale critical and secure supply chains. Defines seven terms. Defines technology coalition as a regional network of organizations, such as private sector, academic, nonprofit, and government institutions, in a network of formal and informal relationships that contribute to technological and economic development in a technology-based industry sector, such as one of ten sectors listed, including artificial intelligence, cybersecurity, and biotechnology. Defines regional area as an area of service by the technology coalition and the focus of economic development metric analysis fir a technology-based industry sector; required to be within State boundaries.
Lists five eligibility criteria for grants, including the applicant having its principal place of operation in the state and certifying that the grant will only be used for allowable purposes solely within the state and will retain its principal place of business in the state for the longer of either the duration in which it receives grant money or a term required by the Office.
Directs that award distribution be based on strategic and tactical needs solely for coalition infrastructure support and coalition cost match allowances for non-State funding. Provides examples of coalition infrastructure support, including developing workforce training programs and supporting private, foundational, and federal grant identification and submission. Authorizes the Board to set a cap on the cost match amount and number of awards per recipient, require applicants to provide matching funds or in-kind support for a grant from the Fund, and provide prioritization in how the Fund may be used by the recipient. 
Directs the Department to develop guidelines for the Fund's administration. Provides public notice and comment requirements prior to the proposed guidelines and any nontechnical amendments, as defined, becoming effective. Authorizes the Department to retain up to $150,000 or 2% of the Fund's appropriation, whichever is greater, for administrative costs.
Appropriates $10.5 million from the General Fund to the Department for 2025-26 to be allocated to the Fund to implement the act. 
Effective July 1, 2025.