H.B. 258
GENERAL ASSEMBLY OF NORTH CAROLINA
Mar 1, 2023
SESSION 2023 HOUSE PRINCIPAL CLERK
H D
HOUSE BILL DRH30119-NI-73
Short Title: Novel Opioid Control Act of 2023. (Public)
Sponsors: Representative Blackwell.
Referred to:
1 A BILL TO BE ENTITLED
2 AN ACT TO UPDATE THE STATE CONTROLLED SUBSTANCES ACT.
3 The General Assembly of North Carolina enacts:
4 SECTION 1.(a) G.S. 90-89(1) reads as rewritten:
5 "(1) Opiates. – Any of the following opiates or opioids, including the isomers,
6 esters, ethers, salts and salts of isomers, esters, and ethers, unless specifically
7 excepted, or listed in another schedule, whenever the existence of such
8 isomers, esters, ethers, and salts is possible within the specific chemical
9 designation:
10 …
11 rrr. Brorphine.
12 sss. AP-237.
13 ttt. 2-methyl AP-237.
14 uuu. (ortho, meta, or para)-methyl AP-237.
15 vvv. AP-238.
16 www. (ortho, meta, or para)-hydroxy 2-methyl AP-237.
17 xxx. 2-Naphthyl U-47700.
18 yyy. 1-Naphthyl U-47700.
19 zzz. 4-(Trifluoromethyl) U-47700.
20 aaaa. Methoxy U-47700.
21 bbbb. Furanyl UF-17.
22 cccc. Cyclopropyl U-47700.
23 dddd. Phenyl U-47700.
24 eeee. Ethyl U-47700.
25 ffff. (2,3- or 3,4)-difluoro-N,N-didesmethyl U-47700.
26 gggg. (2,3- or 3,4)-difluoro U-49900.
27 hhhh. (2,3- or 3,4)-difluoro-N-desmethyl U-47700.
28 iiii. 4-fluoro U-47931E.
29 jjjj. (2,3- or 3,4)-difluoro U-51754.
30 kkkk. (2,3- or 3,4)-difluoro Isopropyl U-47700.
31 llll. (2,3- or 3,4)-difluoro Propyl U-47700.
32 mmmm. (2,3- or 3,4)-difluoro U-50488.
33 nnnn. (2,3- or 3,4)-difluoro U-48800.
34 oooo. (2,3- or 3,4 or 2,4)-difluoro U-47700.
35 pppp. UF-17.
36 qqqq. U-47109.
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 General Assembly Of North Carolina Session 2023
1 rrrr. U-48520.
2 ssss. N,N-didesmethyl U-47700.
3 tttt. U-62066.
4 uuuu. Propyl U-47700.
5 vvvv. (2,3- or 3,4)-Ethylenedioxy U-51754.
6 wwww. 4-phenyl U-51754.
7 xxxx. N-desmethyl U-47700.
8 yyyy. (2,3- or 3,4)-Ethylenedioxy U-47700.
9 zzzz. N-methyl U-47931E.
10 aaaaa. (2,3- or 3,4)-Methylenedioxy U-47700.
11 bbbbb. U-69593.
12 ccccc. U-50488.
13 ddddd. U-48753E.
14 eeeee. U-47931E.
15 fffff. Butonitazene.
16 ggggg. Etodesnitazene (also known as Etonitazepyne).
17 hhhhh. Flunitazene.
18 iiiii. Metodesnitazene.
19 jjjjj. N-Pyrrolidino Etonitazene.
20 kkkkk. Protonitazene."
21 SECTION 1.(b) G.S. 90-89(1a) reads as rewritten:
22 "(1a) Fentanyl derivatives. – Unless specifically excepted, listed in another
23 schedule, or contained within a pharmaceutical product approved by the
24 United States Food and Drug Administration, any compound structurally
25 derived from N-[1-(2-phenylethyl)-4-piperidinyl]-N-phenylpropanamide
26 (Fentanyl) by any substitution on or replacement of the phenethyl group, any
27 substitution on the piperidine ring, any substitution on or replacement of the
28 propanamide group, any substitution on the anilido phenyl group, or any
29 combination of the above unless specifically excepted or listed in another
30 schedule to include their salts, isomers, and salts of isomers. Fentanyl
31 derivatives include, but are not limited to, the following:
32 …
33 f.
34 N-(2-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana
35 mide (also known as 2-fluorofentanyl).(also known as
36 ortho-fluorofentanyl).
37 g.
38 N-(3-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propana
39 mide (also known as 3-fluorofentanyl).(also known as
40 meta-fluorofentanyl).
41 h.
42 N-(1-phenethylpiperidin-4-yl)-N-phenyltetrahydrofuran-2-carbox
43 amide (also known as tetrahydrofuran fentanyl).
44 i.
45 N-(4-fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]
46 -propanamid e (also known as 4-fluoroisobutyryl fentanyl,
47 4-FIBF).(also known as 4-fluoroisobutyryl fentanyl).
48 j. N-(4-fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide
49 (also known as 4-fluorobutyryl fentanyl, 4-FBF).(also known as
50 4-fluorobutyryl fentanyl)."
51 SECTION 1.(c) G.S. 90-89 is amended by adding a new subdivision to read:
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1 "(1b) Nitazene derivatives. – The N-substituted benzimidazole structural class,
2 including any of the following derivatives, their salts, isomers, or salts of
3 isomers unless specifically utilized as part of the manufacturing process by a
4 commercial industry of a substance or material not intended for human
5 ingestion or consumption, as a prescription administered under medical
6 supervision, or for research at a recognized institution, whenever the existence
7 of these salts, isomers, or salts of isomers is possible within the specific
8 chemical designation or unless specifically excepted or listed in this or another
9 schedule, structurally derived from benzimidazole by substitution at the
10 1-position nitrogen with an ethylamine group, and by substitution at the
11 2-position carbon with a benzyl group, whether or not the compound is further
12 modified in any of the following ways:
13 a. By monoalkyl or dialkyl substitution on the 1'-nitrogen of the
14 1-position ethylamine group, or by inclusion of the nitrogen in a cyclic
15 structure;
16 b. By substitution on the 2'-methylene carbon of the benzyl group by
17 alkyl or carboxamide groups;
18 c. By replacement of the 2'-methylene carbon group with an ethylbenzyl,
19 thiophenol, or methoxybenzene group, which may be further
20 substituted with alkyl, hydroxyl, alkoxy, acetoxy, halide, or sulfide
21 groups;
22 d. By substitution at the 2'-position, 3'-position, or 4'-position of the
23 benzyl group, or both, with alkyl, hydroxyl, alkoxy, acetoxy, halide,
24 or sulfide groups; and
25 e. By replacement of a phenyl hydrogen atom at either the 5-position or
26 6-position of the benzimidazole core with a nitro, or primary amine
27 group."
28 SECTION 1.(d) G.S. 90-89(3)v. reads as rewritten:
29 "v. v. 4-bromo-2, 5-dimethoxyamphetamine."
30 SECTION 1.(e) G.S. 90-89(3)mm. reads as rewritten:
31 "mm. 5-methoxy-N-methyl-N-propyltryptamine
32 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT)."
33 SECTION 1.(f) G.S. 90-89(5)j. reads as rewritten:
34 "j. Substituted cathinones. A compound, other than bupropion, that is
35 structurally derived from 2-amino-1-phenyl-1-propanone by
36 modification in any of the following ways: (i) by substitution in the
37 phenyl ring to any extent with alkyl, alkoxy, alkylenedioxy, haloalkyl,
38 or halide substituents, whether or not further substituted in the phenyl
39 ring by one or more other univalent substituents; (ii) by substitution at
40 the 3-position to any extent; or (iii) by substitution at the nitrogen atom
41 with alkyl, dialkyl, benzyl, cycloalkyl, or methoxybenzyl groups or by
42 inclusion of the nitrogen atom in a cyclic structure. For the purpose of
43 this paragraph, the term "isomer" includes the optical, positional, or
44 geometric isomer."
45 SECTION 1.(g) G.S. 90-89(7) reads as rewritten:
46 "(7) Synthetic cannabinoids. – Any quantity of any synthetic chemical compound
47 that (i) is a cannabinoid receptor agonist and mimics the pharmacological
48 effect of naturally occurring substances or (ii) has a stimulant, depressant, or
49 hallucinogenic effect on the central nervous system that is not listed as a
50 controlled substance in Schedules I through V, and is not an FDA-approved
51 drug. Synthetic cannabinoids include, but are not limited to, the substances
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 General Assembly Of North Carolina Session 2023
1 listed in sub-subdivisions a. through p. r. of this subdivision and any substance
2 that contains any quantity of their salts, isomers (whether optical, positional,
3 or geometric), homologues, and salts of isomers and homologues, unless
4 specifically excepted, whenever the existence of these salts, isomers,
5 homologues, and salts of isomers and homologues is possible within the
6 specific chemical designation. The following substances are examples of
7 synthetic cannabinoids and are not intended to be inclusive of the substances
8 included in this Schedule:
9 …
10 n. Indazole carboxaldehydes. Any compound structurally derived from
11 1H-indazole-3-carboxaldehyde or 1H-indazole-2-carboxaldehyde
12 substituted in both of the following ways:
13 …
14 2. At the carbon of the carboxaldehyde by a phenyl, benzyl,
15 naphthyl, adamantyl, cyclopropyl, or propionaldehyde group;
16 whether or not the compound is further modified to any extent
17 in the following ways: (i) substitution to the indazole ring to
18 any extent, (ii) substitution to the phenyl, benzyl, naphthyl,
19 adamantyl, cyclopropyl, or propionaldehyde group to any
20 extent, (iii) a nitrogen heterocyclic analog of the indazole ring,
21 or (iv) a nitrogen heterocyclic analog of the phenyl, benzyl,
22 naphthyl, adamantyl, or cyclopropyl ring.
23 o. Indazole carboxamides. Any compound structurally derived from
24 1H-indazole-3-carboxamide or 1H-indazole-2-carboxamide
25 substituted in both of the following ways:
26 …
27 2. At the nitrogen of the carboxamide by a phenyl, benzyl,
28 naphthyl, adamantyl, cyclopropyl, or propionaldehyde group;
29 whether or not the compound is further modified to any extent
30 in the following ways: (i) substitution to the indazole ring to
31 any extent, (ii) substitution to the phenyl, benzyl, naphthyl,
32 adamantyl, cyclopropyl, or propionaldehyde group to any
33 extent, (iii) a nitrogen heterocyclic analog of the indazole ring,
34 or (iv) a nitrogen heterocyclic analog of the phenyl, benzyl,
35 naphthyl, adamantyl, or cyclopropyl ring. Substances in this
36 class include, but are not limited to: AKB-48, fluoro-AKB-48,
37 APINCACA, AB-PINACA, AB-FUBINACA,
38 ADB-FUBINACA, and ADB-PINACA.
39 …."
40 SECTION 1.(h) G.S. 90-90(2)h1. reads as rewritten:
41 "h1. Fentanyl immediate precursor chemical,
42 4-anilino-N-phenethyl-4-piperidine
43 (ANPP).4-anilino-N-phenethylpiperdine (ANPP)."
44 SECTION 1.(i) G.S. 90-91(k)11. reads as rewritten:
45 "11. Dehydrochlormethyltestosterone,Dehydrochloromethyltestosterone,"
46 SECTION 1.(j) G.S. 90-91(k)16. reads as rewritten:
47 "16. Mesterolene,Mesterolone,"
48 SECTION 2. This act is effective when it becomes law.
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Statutes affected:
Filed: 90-89, 90-90, 90-91
Edition 1: 90-89, 90-90, 90-91
Edition 2: 90-89, 90-90, 90-91
Edition 3: 90-89, 90-90, 90-91, 90-95, 14-17, 14-18.4, 90-96.2