The bill establishes a psilocybin therapeutic use program in Minnesota for individuals aged 21 and older with qualifying medical conditions, allowing them to access psilocybin in a regulated manner. The program, administered by the commissioner of health, focuses on patient safety, compassionate access, and harm reduction, drawing from the state's medical cannabis framework. Key provisions include a secure registration system for tracking patients, eligibility criteria, health screenings, and the ability for registered patients to cultivate psilocybin for personal use. The bill also outlines the roles of registered facilitators, who must supervise psilocybin administration sessions, and establishes protections against civil or criminal penalties for participants in the program.

Additionally, the bill mandates the development of a public education program on responsible psilocybin use and requires training for first responders to handle psilocybin-related situations. It includes provisions for data privacy, ensuring that patient information remains confidential, and introduces a fee structure for program enrollment, with reduced fees for individuals receiving certain disability benefits. The bill also specifies appropriations from the general fund to support the implementation of its provisions, including research on psilocybin's effectiveness for various conditions. Overall, the legislation aims to create a safe and regulated environment for psilocybin use while promoting public education and research.