Creates the EDGE Essentials for Pharmacies and Grocery Stores Act. Creates an income tax credit for taxpayers proposing an eligible pharmacy or eligible grocery store project in Illinois. Provides that the taxpayer may elect to apply the credit against the taxpayer's withholding tax liability. Amends the Illinois Enterprise Zone Act. Provides that a business that is party to an agreement with the Department of Commerce and Economic Opportunity pursuant to the EDGE Essentials for Pharmacies and Grocery Stores Act may receive the benefits of the Illinois Enterprise Zone Act without submitting an application for designation as a High Impact Business. Amends the Grocery Initiative Act. Provides that grants for equipment upgrades may be provided to grocery stores owned and operated by local governmental units and may include reimbursement for investment in point-of-sale systems to accommodate SNAP and WIC transactions. Amends the Illinois Income Tax Act to make conforming changes. Effective immediately.