Creates the Student-Athlete Fairness and Education (SAFE) Act. Requires each public high school to ensure student-athletes receive substance education annually for at least 30 minutes per school year. Sets forth how substance education sessions may be given and what substance education sessions may cover. Provides protection for students with regard to questions or disclosures during substance education sessions and any request for assistance. Requires schools to inform parents of substance education sessions. Allows parents to opt their student-athletes out of substance education sessions for religious or philosophical reasons. Provides that no State reimbursement is required for the implementation of the Act. Sets forth certification requirements in offering substance education. Establishes optional best practices for offering substance education. Includes provisions regarding review of substance education by the State Board of Education and review of the Act by the General Assembly. Makes other changes. Effective January 1, 2027.