Creates the Illinois Affordable Drug Manufacturing Act. Provides that the Department of Human Services shall enter into partnerships with drug companies or manufactures to: (i) increase competition, lower prices, and address shortages in the market for generic prescription drugs; (ii) reduce the cost of prescription drugs for public and private purchasers, taxpayers, and consumers; and (iii) increase patient access to affordable drugs. Provides that such partnerships shall be made with the intent to ensure the wide availability of generic prescription drugs to public and private purchasers, providers and suppliers, and pharmacies as appropriate. Requires that such drugs must be produced or distributed by a drug company or generic drug manufacturer that is registered with the United States Food and Drug Administration. Sets forth price setting criteria and a list of the most common generic prescription drugs that are to be produced and distributed through the partnerships. Requires the Department to consult with other State agencies, licensed health care service plans, health insurers, hospitals, and pharmacy benefit managers in maintaining the list of generic prescription drugs. Contains provisions concerning minimum drug procurement thresholds; reporting requirements; and other matters. Makes implementation of the Act subject to appropriation. Effective immediately, except that certain provisions take effect on January 1, 2029.